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31) Undifferentiated pleomorphic sarcoma (UPS) is a high-grade soft tissue sarcoma composed of undifferentiated mesenchymal cells with pleomorphic fibrohistiocytic features and no identifiable line of differentiation, making it a diagnosis of exclusion under the current WHO classification (Fig

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The peptides anti-inflammatory effects operate through several interconnected pathways

Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus

Many of these symptoms are also present in the thiamine deficiency states (137), supporting involvement of ACP2 in thiamine metabolism

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